{"id":1550,"date":"2017-07-20T14:22:39","date_gmt":"2017-07-20T12:22:39","guid":{"rendered":"https:\/\/www.optimhal-protecsom.com\/deposition\/en\/?page_id=1550"},"modified":"2022-06-27T15:03:18","modified_gmt":"2022-06-27T13:03:18","slug":"combihaler-spacer","status":"publish","type":"page","link":"https:\/\/optimhal.com\/en\/combihaler-spacer\/","title":{"rendered":"CombiHaler spacer"},"content":{"rendered":"

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Spacer for mechanical ventilation circuit<\/span><\/strong><\/em><\/h4>\n
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The CombiHaler\u00ae<\/sup>\u00a0is 100% designed and manufactured in France. CombiHaler\u00ae<\/sup>\u00a0spacer for mechanical ventilation and critical care (ICU) enables the use of both a vibrating mesh nebuliser such as Aerogen\u00ae<\/sup>, and a pMDI at the same time.<\/p>\n

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Specifications<\/span><\/span><\/strong><\/span><\/h4>\n<\/div><\/div>
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Benefits<\/span>\u00a0<\/span><\/strong><\/span><\/h4>\n<\/div><\/div>
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Scientific publications<\/span><\/span><\/strong><\/span><\/h4>\n<\/div><\/div><\/div>\n
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<\/a>Specifications of the spacer\u00a0CombiHaler\u00ae<\/sub><\/sup><\/strong><\/span><\/h3>\n
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CombiHaler\u00ae<\/sup>\u00a0is a device aimed to improve respiratory drug deposition for ventilated patients in critical care (ICU). It was designed to enable the use of a pMDI and an Aerogen\u00ae<\/sup>\u00a0together.\u00a0<\/strong><\/p>\n

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Description\u00a0of the device and its intended use<\/strong><\/span><\/h5>\n
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CombiHaler\u00ae<\/sup>\u00a0is a spacer designed to be integrated on a breathing device circuit in invasive or non-invasive ventilation. It enables the connection of a pMDI and\/or an Aerogen\u00ae<\/sup>\u00a0Pro or an Aerogen\u00ae<\/sup>\u00a0Solo without intervention on circuit.<\/p>\n

CombiHaler\u00ae<\/sup>\u00a0is intended to administer drugs by both nebulizer and pressurized metered dose inhaler (pMDI). It limits in particular\u00a0the impaction deposit or the substance in the spacer.<\/p>\n<\/div><\/div><\/div>\n<\/p>

The CombiHaler\u00ae<\/sup> spacer is single use only and is meant to be used in hospital, in intensive care services or for home care.<\/p>\n

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Who is it for\u00a0?<\/strong><\/span><\/h5>\n
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It is intended for patients suffering from Chronic Obstructive Pulmonary Disease (COPD), asthma or chronic obstructive respiratory insufficiency in pulmonology, critical care or operating suite.<\/p>\n

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How does the\u00a0CombiHaler\u00ae <\/sup>spacer work ?<\/strong><\/span><\/h5>\n
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The spacer is meant to be crossed by gas flows in a circuit of a device for mechanical ventilation.<\/p>\n

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CombiHaler\u00ae<\/sup> has four openings leading to its inside volume. The CombiHaler\u00ae spacer has two openings meant to be connected to the respirator circuit: one openings is meant for the way in of the gas flow and the other one is meant for the way out of the gas flow. CombiHaler\u00ae<\/sup>\u00a0also has an opening to plug a pressurised metered dose inhaler and an opening to plug a nebuliser\u00a0Aerogen\u00ae<\/sup>\u00a0Pro or Aerogen\u00ae<\/sup>\u00a0Solo.<\/p>\n

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The openings to plug the pMDI and the nebuliser\u00a0Aerogen\u00ae<\/sup>\u00a0Pro or Aerogen\u00ae<\/sup>\u00a0Solo are both formed in the upper part of the inhalation chamber. The positioning of the openings that are used to plug the pMDI and the nebulizer, not facing but one adjacent the other, make it possible to avoid the deposit related to the impaction of the particles, for example, produced by the Aerogen\u00ae<\/sup>\u00a0Pro or Aerogen\u00ae<\/sup>\u00a0Solo nebuliser on the inhaler or vice versa.<\/p>\n

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<\/i> Download the CombiHaler\u00ae<\/sup> user manual<\/span><\/a>\n<\/p>

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<\/a>What are the benefits\u00a0?<\/strong><\/span><\/h3>\n
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Connect an Aerogen\u00ae<\/sup>\u00a0on a ventilation circuit through a CombiHaler\u00ae<\/sup>\u00a0provides significant benefits for ventilated patients and caregivers.<\/strong><\/p>\n

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1.<\/strong>\u00a0<\/em><\/span>Save\u00a050% of the nebulized drug: \u00a0Used to be connected to an Aeroneb\u00ae<\/sup> Pro ou un Aerogen\u00ae<\/sup>\u00a0Solo, CombiHaler\u00ae<\/sup>\u00a0provides a pulmonary deposition of nebulized medication twice the traditional assembly with T piece (It is 40% with the Amikacine). Regarding the price of some drugs, it can represent a real benefit.<\/p>\n

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2.<\/strong><\/em><\/span>\u00a0<\/span>Using a CombiHaler\u00ae<\/sup> with an Aerogen\u00ae<\/sup> and a pMDI on a ventilation circuit simplifies it as it is possible to use only one device instead of two.<\/p>\n

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3.<\/em><\/strong><\/span>\u00a0<\/span>Using the CombiHaler\u00ae<\/sup> does not modify the respirator parameters<\/p>\n

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4.<\/em>\u00a0<\/strong><\/span>As it is transparent, CombiHaler\u00ae<\/sup> do not bother the monitoring of the ventilation circuit.<\/p>\n

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5.<\/em><\/strong>\u00a0<\/span>As a single patient device, CombiHaler\u00ae<\/sup>\u00a0can be used during the lifespan of the ventilation system.<\/p>\n

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CombiHaler\u00ae\u00a0<\/sup>and\u00a0COVID-19 :\u00a0an appropriate spacer<\/strong><\/span><\/h3>\n
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During the Covid-19 pandemic, it is recommended to use an inhaler. CombiHaler\u00ae<\/sup> enables and facilitates this use on ventilation circuits.<\/p>\n

If it not possible to switch from a pMDI treatment to a nebulized treatment, it is then recommended to use a vibrating mesh nebuliser. As its drug tank is isolated from the circuit, it enables to avoid the infection of the drug solution.<\/p>\n

CombiHaler\u00ae<\/sup> can be used with a pMDI as well as a vibrating mesh nebulizer. CombiHaler\u00ae<\/sup> make it possible to go through a device to another, thus, avoiding to infect the patient environment.<\/p>\n<\/div><\/div>\n

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<\/a>Proven effectiveness in the scientific literature\u00a0 :<\/strong><\/span><\/p>\n

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Naughton PJ et al, Evaluation of Aerosol Delivery options during Adult Mechanical Ventilation in the COVID-19 Era (2021), Pharmaceutics, 13:1574.<\/strong><\/a><\/p>

Seif et al, Aerosol delivery of inhalation devices with different add-on connections to invasively ventilated COPD subjects: An in-vivo study (2021), European Journal of Pharmaceutical Sciences, 167: 105988.<\/a><\/strong><\/p>

Seif et al, Effect of different connection adapters on aerosol delivery in invasive ventilation setting; an in-vitro study (2021), journal of Drug Delivery Science and Technology, 61:102177.<\/a><\/strong><\/p>

Rashad et al, Performance of different add-on devices in dual limb non-invasive mechanically ventilated circuit (2021), Journal of Drug Delivery Science and technology, 66:102897.<\/a><\/strong><\/p>

Saeed et al, Effect of different connections on aerosol delivery during non-invasive mechanical ventilation (2020), European Respiratory journal, 56:1950.<\/a><\/strong><\/p>

Saeed et al, In-Vitro evaluation of the performance of some large volume spacer versus T-adapters (2020), European respiratory journal, 56:2747.<\/a><\/strong><\/p>

Mohamed et al, Lung deposition and systemic bioavailability of dose delivered to smoker compared with non-smoker COPD subjects (2020), International Journal of Clinical Practice, 75:13883.<\/a><\/strong><\/p>

Rodriguez et al, In vitro evaluation of aerosol delivery of aztreonam lysine (AZLI): an adult mechanical ventilation model (2017), Expert Opinion on Drug delivery, 14: 1447.<\/a><\/strong><\/p>

Madney et al, Nebulizers and spacers for aerosol delivery through adult nasal cannula at low oxygen flow rate: An in-vitro study (2017), Journal of drug Delivery science and technology, 39:260.<\/a><\/strong><\/p>

Madney et al, Aerosol delivery through an Adult High-Flow Nasal Cannula Circuit Using Low-Flow Oxygen (2019), Respiratory Care, 64:453.<\/a><\/strong><\/p>

Harb et al, Is Combihaler usable for aerosol delivery in single limb non-invasive mechanical ventilation ? (2017), Journal of drug delivery Science and Technology, 40 : 28.<\/a><\/strong><\/p>

Boukhettala et al, In vitro performance of Spacers for Aerocol Delivery during Adult Mechanical Ventilation (2014), Journal of Aerosol Medicine and Pulmonary Drug Delivery, 27: 1.<\/a><\/strong><\/p>\n<\/div><\/div>\n

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Scientifics publications
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Aerosol delivery and Mechanical Ventilation: In vitro evaluation of spacers for use with a pressurized-metered dose inhaler (pMDI) and a vibrating mesh nebulizer (VMN) in comparison with T adapters.<\/strong><\/a><\/p>\n

RFMV 2020 :<\/strong>\u00a0M. Eckes, B. Demouveaux, B. Hervieu, A. Paris, A. Vanlaeys, T. Por\u00e9e.<\/em><\/p>

Effect of spacer volume on drug delivery using mechanical ventilation: An in vitro study.<\/strong><\/a><\/p>\n

RDD 2019 :<\/strong>\u00a0M. Eckes, T. Por\u00e9e.<\/em><\/p>

In vitro evaluation of spacers in comparison with T-adapters in mechanical ventilation with pMDI and vibrating mesh nebulizer.<\/strong><\/a><\/p>\n

ERS 2019<\/strong>\u00a0:\u00a0M. Eckes, T. Por\u00e9e.<\/em><\/p>

In vitro evaluation of a new spacer with Respimat\u00ae in mechanical ventilation.<\/strong><\/a><\/p>\n

ISAM 2015 :<\/strong>\u00a0N. Boukhettala , T. Por\u00e9e , P. Diot , L.Vecellio.<\/em><\/p>

In vitro evaluation of a spacer in a pediatric model of mechanical ventilation<\/a>.<\/strong><\/p>\n

CIPP 2015 :<\/strong>\u00a0N. Boukhettala, T. Por\u00e9e.<\/em><\/p>

In Vitro<\/em>\u00a0Performance of Spacers for Aerosol Delivery during Adult Mechanical Ventilation<\/strong>.<\/a><\/p>\n

2014\u00a0 [Epub ahead of print]<\/strong>\u00a0:\u00a0N.\u00a0Boukhettala , T. Por\u00e9e , P. Diot , L. Vecellio.<\/em><\/p>

Study of the performances of a new spacer in mechanical ventilation.<\/strong><\/a><\/p>\n

ISAM 2013 :<\/strong>\u00a0N. Boukhettala , T. Por\u00e9e , P. Diot , L. Vecellio.<\/em><\/p>

Study Of The Effectiveness Of A New Inhalation Chamber In Invasive Mechanical Ventilation.\u00a0<\/strong><\/a><\/p>\n

ATS 2012<\/strong>\u00a0:\u00a0<\/strong>N. Boukhettala, P. Diot, T. Por\u00e9e, L.\u00a0Vecellio.<\/em><\/a><\/span><\/p>

A new Spacer for pMDI and nebulizers in mechanical ventilation.\u00a0<\/strong><\/a><\/p>\n

ERS 2012<\/strong>\u00a0:\u00a0N. Boukhettala, P. Diot, T. Por\u00e9e\u00a0, L. Vecellio.<\/em><\/a><\/span><\/p>

Study Of The Effectiveness Of A New Inhalation Chamber In Invasive Mechanical Ventilation.\u00a0<\/strong><\/a><\/p>\n

Abstract ATS 2012<\/strong>\u00a0:\u00a0N. Boukhettala, P. Diot, L. Vecellio.<\/em><\/a><\/span><\/p>

Study of the performances of a new spacer in mechanical ventilation.<\/a>\u00a0<\/strong><\/p>\n

N. Boukhettala , T. Por\u00e9e , P. Diot, L. Vecellio.<\/em><\/a><\/span>
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Is Combihaler\u00ae<\/sup>\u00a0usable for aerosol delivery in single limb non-invasive mechanical ventilation?<\/a><\/strong><\/p>\n

Hadeer S. Harb Bsc, Ahmed A. Elberry, Hoda Rabea, Maha Fathy, Mohamed E.A Abdelrahim.<\/em><\/p>\n<\/div><\/div>\n

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<\/i> Discover CombiHaler\u00ae<\/sup> Solo<\/span><\/a><\/div>\n
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The trademark\u00a0Aerogen\u00ae<\/sup>\u00a0belongs to The Aerogen Company Limited.<\/span><\/p>\n

The trademark\u00a0CombiHaler\u00ae<\/sup>\u00a0belongs to ProtecSom-OptimHal SAS. Patents belong to Tour University, INSERM, and OptimHal-ProtecSom SAS together.
\n<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Spacer for mechanical ventilation circuit The CombiHaler\u00ae\u00a0is 100% designed and manufactured in France. CombiHaler\u00ae\u00a0spacer for mechanical ventilation and critical care (ICU) enables the use of both a vibrating mesh nebuliser such as Aerogen\u00ae, and a pMDI at the same time. The trademark\u00a0Aerogen\u00ae\u00a0belongs to The Aerogen Company Limited. The trademark\u00a0CombiHaler\u00ae\u00a0belongs to ProtecSom-OptimHal SAS. Patents belong to […]<\/p>\n","protected":false},"author":7,"featured_media":0,"parent":0,"menu_order":25,"comment_status":"closed","ping_status":"closed","template":"fondblanc-page.php","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1550","page","type-page","status-publish","hentry"],"yoast_head":"\nCombiHaler spacer - D\u00e9position Pulmonaire des M\u00e9dicaments<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/optimhal.com\/en\/combihaler-spacer\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"CombiHaler spacer - D\u00e9position Pulmonaire des M\u00e9dicaments\" \/>\n<meta property=\"og:description\" content=\"Spacer for mechanical ventilation circuit The CombiHaler\u00ae\u00a0is 100% designed and manufactured in France. CombiHaler\u00ae\u00a0spacer for mechanical ventilation and critical care (ICU) enables the use of both a vibrating mesh nebuliser such as Aerogen\u00ae, and a pMDI at the same time. The trademark\u00a0Aerogen\u00ae\u00a0belongs to The Aerogen Company Limited. The trademark\u00a0CombiHaler\u00ae\u00a0belongs to ProtecSom-OptimHal SAS. Patents belong to […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/optimhal.com\/en\/combihaler-spacer\/\" \/>\n<meta property=\"og:site_name\" content=\"D\u00e9position Pulmonaire des M\u00e9dicaments\" \/>\n<meta property=\"article:modified_time\" content=\"2022-06-27T13:03:18+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/optimhal.com\/wp-content\/uploads\/sites\/5\/2017\/01\/Logo_chambre_d_inhalation_pour_circuit_de_ventilation_CombiHaler_pour_aerosol-doseur_et_nebuliseur.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"4220\" \/>\n\t<meta property=\"og:image:height\" content=\"1285\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"7 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/optimhal.com\/en\/combihaler-spacer\/\",\"url\":\"https:\/\/optimhal.com\/en\/combihaler-spacer\/\",\"name\":\"CombiHaler spacer - D\u00e9position Pulmonaire des M\u00e9dicaments\",\"isPartOf\":{\"@id\":\"https:\/\/optimhal.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/optimhal.com\/en\/combihaler-spacer\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/optimhal.com\/en\/combihaler-spacer\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/www.optimhal-protecsom.com\/deposition\/wp-content\/uploads\/sites\/5\/2017\/01\/Logo_chambre_d_inhalation_pour_circuit_de_ventilation_CombiHaler_pour_aerosol-doseur_et_nebuliseur-300x91.jpg\",\"datePublished\":\"2017-07-20T12:22:39+00:00\",\"dateModified\":\"2022-06-27T13:03:18+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/optimhal.com\/en\/combihaler-spacer\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/optimhal.com\/en\/combihaler-spacer\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/optimhal.com\/en\/combihaler-spacer\/#primaryimage\",\"url\":\"https:\/\/www.optimhal-protecsom.com\/deposition\/wp-content\/uploads\/sites\/5\/2017\/01\/Logo_chambre_d_inhalation_pour_circuit_de_ventilation_CombiHaler_pour_aerosol-doseur_et_nebuliseur-300x91.jpg\",\"contentUrl\":\"https:\/\/www.optimhal-protecsom.com\/deposition\/wp-content\/uploads\/sites\/5\/2017\/01\/Logo_chambre_d_inhalation_pour_circuit_de_ventilation_CombiHaler_pour_aerosol-doseur_et_nebuliseur-300x91.jpg\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/optimhal.com\/en\/combihaler-spacer\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Accueil\",\"item\":\"https:\/\/optimhal.com\/en\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"CombiHaler spacer\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/optimhal.com\/#website\",\"url\":\"https:\/\/optimhal.com\/\",\"name\":\"D\u00e9position Pulmonaire des M\u00e9dicaments\",\"description\":\"Chambres d\u2019inhalation\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/optimhal.com\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"CombiHaler spacer - D\u00e9position Pulmonaire des M\u00e9dicaments","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/optimhal.com\/en\/combihaler-spacer\/","og_locale":"en_US","og_type":"article","og_title":"CombiHaler spacer - D\u00e9position Pulmonaire des M\u00e9dicaments","og_description":"Spacer for mechanical ventilation circuit The CombiHaler\u00ae\u00a0is 100% designed and manufactured in France. CombiHaler\u00ae\u00a0spacer for mechanical ventilation and critical care (ICU) enables the use of both a vibrating mesh nebuliser such as Aerogen\u00ae, and a pMDI at the same time. The trademark\u00a0Aerogen\u00ae\u00a0belongs to The Aerogen Company Limited. The trademark\u00a0CombiHaler\u00ae\u00a0belongs to ProtecSom-OptimHal SAS. 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